About This Project
Human lifespan has long been a topic of discussion and interest in the United States and throughout the world; people want to know how they can live longer. By investigating demographic data from the United States and India, we have found a relationship between average internal body temperature, outdoor ambient temperature, and human lifespan. We hope to further investigate these relationships which may in turn allow for the development of new methods to prolong human lifespan.
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What is the context of this research?
Humans are predicted to have a maximal average life span of about 104 years and a maximum age of 115 years. But what factors govern this parameter besides biochemical mechanisms such as reactive oxygen species or telomere truncation? One major subject of recent interest has been ambient temperature and its effect on human senescence at a macro-level. Meta-analysis is necessary to digest the trends in average life span across geographic regions.
What is the significance of this project?
The significance of this project is that it could lead to the development of new methods to increase human lifespan. Current evidence suggests that internal body temperature does indeed influence human lifespan. By decreasing average internal body temperature, it is likely that human lifespan can be increased. Discovering the influence of outdoor ambient temperature on internal body temperature will allow for a better understanding of how human lifespan can be increased via temperature control. Additional research could then investigate the optimal temperature for an increase in lifespan without an increase in disease risk. The results of this project could create a research field that focuses on the implementation of temperature control to prolong human life.
What are the goals of the project?
The primary goal of this project is to determine if outdoor ambient temperature has an effect on human lifespan. A large amount of work has already been performed through the analysis of past research as well as demographic data of the United States and India. By gathering data regarding average internal body temperature, outdoor ambient temperature, and human lifespan, a mortality function has been developed with these variables. With an additional variable for the external factors that influence human lifespan such as health care, epidemic diseases, etc., the mortality function has revealed a relationship between outdoor ambient temperature and human lifespan in India but not the United States. Further analysis will allow us to explain and reinforce our current findings.
Data on annual trends in life span and ambient temperatures is crucial for our research. Additional data is needed to further support our current findings. We intend to analyze this data and derive mathematical relationships that refine what has previously been established by Dr. Xiaoping Liu. This data is not freely available, therefore funds are required to gain access to these databases.
Meet the Team
Bipul is a current undergraduate researcher at the Ohio State University College of Medicine. Under the guidance of Dr. Xiaoping Liu, he has participated in research involving nitrous oxide and its role in vasculature. Particularly, the consumption of NO in the blood vessel is of interest. More recently, he took an interest to a project revolving around human senescence and factors such as ambient temperature and auxiliary environmental factors that can affect it. He hopes to help gather data that can shift our thinking of senescence make great strides in the field as he pursues his future in medicine.
Benjamin Crawford is a fourth year undergraduate student at The Ohio State University. He plans on attending medical school after graduation to pursue a career as a clinical physician. His work with Dr. Xiaoping Liu has consisted of data collection, analysis, and presentation in the fields of senescence and vascular biochemistry. Human lifespan has been of particular interest to him as he and his team continue to learn more about the many variables that influence its length. He plans on further contributing to senescence research throughout his career.
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