One of the main questions in my laboratory is how experience modulates brain function. We began an
investigation of how memory traces are represented in the organization and architecture of neuronal
ensembles and synaptic circuits in the rodent hippocampus. We wish to provide a comprehensive
understanding of how the brain changes with learned experiences by attempting to bridge the current gaps
between neuronal ensemble activity, synaptic circuit function and molecular mechanisms that support memory.
Malfunction of experience-dependent modulation of neuronal and synaptic circuits may be a prominent cause
of neurological disorders. This research will lay the groundwork towards research on memory-associated
modulation of neuronal circuits in mouse models of neurological disorders to gain insight into potential
corrections of circuit function that could lead to treatments to improve cognitive outcome.