I am sorry that I was unable to raise enough funds to launch this project, but I deeply appreciate the generosity and support of those who contributed. Thank you all once again. I will continue working hard to bring this project to life and look forward to fruitful collaborations with you in the near future.
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About This Project
CRISPR Prime Editing (PE)-mediated gene integration holds promise for treating genetic diseases and enhancing crops but faces challenges in efficiency, payload capacity, and genetic baggage. This project engineers integrases to boost integration efficiency and capacity, enabling larger genetic manipulation. By designing orthogonal circuitry to autonomously exclude unwanted vector elements, we achieve clean, exclusive integration for impactful applications in medicine and agriculture.
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