TH levels track with motor coordination

Principally, Parkinson's Disease (PD) is a lack of motor coordination due to loss of dopaminergic activity, canonically ascribed to neuronal loss. However, tyrosine hydroxylase (TH) is the rate limiting enzyme of dopamine metabolism, and loss of TH, may precede neuronal death. This study will correlate TH with motor function in a model of PD. Thus, TH biology may provide novel strategies for PD treatment.