Exosomes are cell derived nanovesicles found in all body fluids that mediate intercellular communication and are currently viewed as promising biomarkers for health and disease. Obesity is a pandemic problem and many efforts have been dedicated for cure with scarce success. Cold exposure induces "non-shivering" thermogenesis, which dissipates energy and produces heat in some fat depots. In this project we intend to evaluate cold-released exosomes as therapeutic tool to fight obesity.