Our bodies produce very low doses of N,N-Dimethyltryptamine (DMT), a psychotropic substance. Recent findings suggest that DMT is an important modulator of Sig-1R, a receptor that plays important roles in neuropsychiatric diseases like schizophrenia, and depression. This project aims to further develop a hypothesis for the relation between DMT and Sig-1R, in hopes of providing novel insight into these neuropsychiatric diseases.