{"model":{"id":2604,"update_text":"

First Progress Update

Hi All,

First I want to say thank you so much to everyone involved in making this project a reality! I am deeply grateful to everyone who donated, everyone who took the time to read the proposals, and especially to Devin and Shannon for organizing this whole thing.

That said, let me update you on my project, level by level:

1) The genomic level: The genomic potential for all samples has been determined using the PICRUSt software and we have compared the HIV infected and uninfected samples. Hundreds of KEGG terms are significantly different between the groups but only one pathway, flavonoid biosynthesis, is significant.

2) The transcriptomic level: Samples are being organized at Pitt to be sent to NYU so I can process and sequence them. I'm excited to get away from my computer and into the wet lab for a little while when they come!

3) The metabolomic level: This work was done by collaborators at Emory University. They found 12 differentially expressed m/z features (metabolites) and have used network analysis to associate them with the bacteria present in the lungs. The paper is being circulated among the authors and I'll post it here as soon as it's published.

Once again, thank you all very much. I look forward to letting you know as everything continues to develop.

Cheers, Laura

","title":"First Progress Update","backers_only":false,"published_at":"2015-01-25T16:58:03.000-08:00","view_count":39,"publish_on":null,"url":"https://experiment.com/u/xj0S6Q","image":null,"project_title":"Short-Term Innovative Research (STIR): Predoctoral Grant Competition","project_link":"https://experiment.com/projects/short-term-innovative-research-stir-predoctoral-grant-competition","project_id":"short-term-innovative-research-stir-predoctoral-grant-competition","user_id":22016,"likes":1,"comments":0,"save_url":"/updates/save","editor":"redactor","citations":[],"new_record":false,"is_published":true,"is_draft":false,"save_path":"/updates/save","file_attachments":[],"tags":[],"text_to_be_jsonified_for_read":"

First Progress Update

Hi All,

That said, let me update you on my project, level by level:

Once again, thank you all very much. I look forward to letting you know as everything continues to develop.

Cheers, Laura

","project_milestones":[],"completed_milestones":[],"edit_milestones_path":"/projects/short-term-innovative-research-stir-predoctoral-grant-competition/wizard#milestone","base_path":"/projects/short-term-innovative-research-stir-predoctoral-grant-competition/updates/xj0S6Q","class_name":"Update","json_for_read":{"document":{"data":{},"key":"43","kind":"document","nodes":[{"data":{},"key":"45","kind":"block","isVoid":false,"type":"heading-one","nodes":[{"key":"44","kind":"text","ranges":[{"kind":"range","text":"First Progress Update","marks":[]}]}]},{"data":{},"key":"28","kind":"block","isVoid":false,"type":"paragraph","nodes":[{"key":"27","kind":"text","ranges":[{"kind":"range","text":"Hi All,","marks":[]}]}]},{"data":{},"key":"30","kind":"block","isVoid":false,"type":"paragraph","nodes":[{"key":"29","kind":"text","ranges":[{"kind":"range","text":"First I want to say thank you so much to everyone involved in making this project a reality! 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I look forward to letting you know as everything continues to develop.","marks":[]}]}]},{"data":{},"key":"42","kind":"block","isVoid":false,"type":"paragraph","nodes":[{"key":"41","kind":"text","ranges":[{"kind":"range","text":"Cheers, Laura","marks":[]}]}]}]},"kind":"state"},"json_for_write":{"document":{"data":{},"key":"43","kind":"document","nodes":[{"data":{},"key":"45","kind":"block","isVoid":false,"type":"heading-one","nodes":[{"key":"44","kind":"text","ranges":[{"kind":"range","text":"First Progress Update","marks":[]}]}]},{"data":{},"key":"28","kind":"block","isVoid":false,"type":"paragraph","nodes":[{"key":"27","kind":"text","ranges":[{"kind":"range","text":"Hi All,","marks":[]}]}]},{"data":{},"key":"30","kind":"block","isVoid":false,"type":"paragraph","nodes":[{"key":"29","kind":"text","ranges":[{"kind":"range","text":"First I want to say thank you so much to everyone involved in making this project a reality! 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First Progress Update

Hi All,

That said, let me update you on my project, level by level:

Once again, thank you all very much. I look forward to letting you know as everything continues to develop.

Cheers, Laura

","private":false},"initialComments":[]}