Cats are fast. There are very large nerve cells in the motor cortex of mammals known as Gigantopyramidal neurons. Our project explores these neurons for the first time in a wide variety of mammals. We are especially focused on the larger felids such as the clouded leopard, Siberian tiger, and African lion. Preliminary studies suggest these neurons are particularly large in cats, and this comparative study may reveal why, and provide insight into the exact function of these cells.