About This Project
Some South American opossums have a blood protein (vWF) which has evolved resistance to snake venom. Our lab examines how three venom proteins interact and evolve with vWF. However, necessary data for one of these proteins, Aspercetin, are lacking. This project aims to sequence Aspercetin and obtain the crystal structure of vWF complexed with Aspercetin, to understand how this protein has evolved to target vWF, and how opossums have co-evolved to combat its deadly function.