CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a rare genetic disease with no current cure, profoundly impacting those affected. Symptoms of CADASIL often start in early adulthood and progresses to recurrent strokes, cognitive difficulties, and ultimately, vascular dementia. In my laboratory, we have developed a groundbreaking in vitro model, ‘CADASIL in a dish’, which allows us to study the disease and explore potential treatments.