Ophidiomycosis (snake fungal disease) is a threat to snake health. Caused by the fungus Ophidiomyces ophiodiicola, it affects over 30 wild snake species and can cause skin abnormalities, internal lesions, and even death. Differences in disease signs may be due to snakes' response to infection. We plan to measure innate immune function in Lake Erie watersnakes with a range of ophidiomycosis lesions to determine if disease severity is associated with immune function.