The first step: microRNAs

Jun 09, 2015

The first step: microRNAsThe role of small non-coding microRNA (miRNAs) has become essential for gene regulation in a variety of human diseases. In this short video, expression and function of miRNAs is nicely explained!
                                  
How do miRNAs work? mRNA encodes for proteins, but protein synthesis is inhibited when a miRNA molecule comes along and physically blocks translation. Consequently, anti-microRNA molecules can up-regulate protein production.
We're hoping to identify the miRNAs molecules in extracellular vesicles (EV) and what they do, to learn how EVs function and target cells they move between.
In short, miRNAs affect how EVs function, and EVs can be a tool used to target diseased cells. So helping us fund the first step of looking at miRNAs is the foundation for targeted drug therapy down the line.
Enjoy and please ask if you have any question on miRNAs!!!

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About This Project

You have mail: Stem Cell messages for fighting liver diseases

University of California San Diego

The use of stem cells is currently limited by issues including the risk of tumor formation or undesired immune responses. However, stem cells represent a promising therapeutic approach for several diseases. Stem cells release round packets called Extracellular vesicles (EVs) which carry and deliver specific messages to target cells. We believe that these extracellular stem cell vesicles deliver important regenerative signals to liver cells, which may counter the progression of liver diseases.