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Project Outcomes (as of May 2nd, 2023)

2 May 2023

Summary.  There have been five outcomes from this project at the present time, which include the following:

(1) Patent Application. “Tetrazolium-Based Colorimetric Assay” by Edward L. D'Antonio and Gustavo F. Mercaldi (2023) Filed with the United States Patent and Trademark Office.

(2) Invited Guest (Dr. Edward L. D’Antonio). ISNTD Connect.  Live recording in London, England by the International Society for Neglected Tropical Diseases,  17 March 2023. "Chagas’ Disease and Human African Trypanosomiasis Drug Discovery: Trypanosoma cruzi Glucokinase as a Potential Drug Target."  Presentation Link: https://www.isntd.org/isntd-connect

(3) Presenter (Triet M. Pham). “Rapid, Novel, and Sensitive Tetrazolium-Based Colorimetric Assay for Helicase nsp13 in SARS-CoV-2" (co-authored by Morgan G. Howard, Shane M. Carey, Gustavo F. Mercaldi, and Edward L. D'Antonio).    (a) 32nd Annual Molecular Parasitology & Vector Biology Symposium, University of Georgia, Athens, Georgia (2 May 2023).    (b) 2023 Discover USC, Columbia, South Carolina (21 April 2023).    (c) 2023 USCB Student Research and Scholarship Day, Bluffton, South Carolina (17 April 2023); awarded 1st place in the "Innovation" category.

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About This Project

Therapeutics in any modality to combat Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections are in urgent demand across the entire world as the Coronavirus Disease 2019 (COVID-19) pandemic continues to interrupt the well-being of human life. Without clinical therapeutics available for any of the human coronaviruses, a key starting point is to focus on target-based high-throughput screening (HTS) to reveal potent anti-SARS-CoV-2 hit-to-leads that are safe to human cells.

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