Gail A. Bishop

Gail A. Bishop

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David, Thank you for your interest. But I want to clear up some areas of confusion. B cells express TRAF3 constitutively; they don't need exogenous stimuli. The nanoparticles are to enhance B cell uptake of antigen and adjuvant signals, which in turn makes them more effective APC. My lab performed a proof-of-concept of the B cell vaccine approach in an infectious disease mouse model; you can find the paper in The Journal of Immunology (2009). This paper would give you a clearer idea of our approach than I could provide in a quick paragraph. Using the approach for tumors is newer for us, and we need to do more work to be certain of the molecular mechanisms. We do know thta CD8 T cell activation is stimulated, but are not sure of the role of macrophages at this point. Best, GB
Nov 24, 2015
Using Nanoparticles to Activate Immune Cells to Fight Tumors
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I'm sorry you got that incorrect impression, David. We are using Bvac as antigen presenting cells, NOT to make antibodies. This is quite a different goal. Regards, GB
Nov 18, 2015
Using Nanoparticles to Activate Immune Cells to Fight Tumors
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Thank you for the kind words, Annie. Much appreciated. Happy holidays, Gail
Dec 18, 2014
Using Nanoparticles to Activate Immune Cells to Fight Tumors
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Jeff, Many thanks for your interest and support. Brett will be sending you a published report from our lab and a recent review article that explains more about this approach and our rationale. Regards, Gail Bishop
Oct 31, 2014
Using Nanoparticles to Activate Immune Cells to Fight Tumors
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Thank you, Allen! That is really appreciated. Gail
Oct 28, 2014
Using Nanoparticles to Activate Immune Cells to Fight Tumors
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