University of Oklahoma Health Sciences Center
I have a broad background in Cancer and stem cell biology, gastroenterology and endocrinology with extensive training and experience in molecular and cellular biology and animal models relevant to the background knowledge. I carried out research investigating the role of NF-kB/b-catenin/Notch signaling during intestinal crypt hyperplasia and neoplasia. I expanded my research to include the isolation, purification and characterization of intestinal, pancreatic, hepatic, colon and breast stem cells. We have established a tumor stem cell marker, DCLK1, and found it to be upregulated in many cancers. Recently I have established the functional importance of DCLK1 as a protein enhances breast tumorigenesis. My research experience and scientific expertise in the field of stem cell and bresast cancer biology have prepared me to successfully carry out this research.