Love for "brain" started during my Vet School in Naples at "Univeristà degli Studi di Napoli Federico II", in particular thanks to anatomy, neurology and neurosurgery classes, these lighted the fire for research. After becoming DVM, I start PhD course "Model Organisms for Biomedical and Veterinary Research". It gives me the chance to combine my major interests with the study of laboratory models, used during the research, in particular focused on the comparative neuroanatomy. My goal is find out which are the mechanisms that influence and change the brain structure and function during the aging process. Well, I would like give my contribute to help people with diseases correlated with aging. Also, I would like to find the way to resolve the ethical issue, that involve using animals in researching, applying the 3Rs rules and helping the ethics committees to find the best combination.