University of Kansas
During my PhD studies at the Technion (Israel Institute of Technology), I have investigated the role of the ubiquitin system in protein post-transnational modification and degradation under the supervision of Dr. Hershko and Dr. Ciechanover (2004 Nobel laureates in Chemistry). Since then, I have been engaged in research of another less explored but yet important protein post-translational modification that is enhanced upon oxidative stress, namely: methionine sulfoxide (MetO). I have extensively studied the role of MetO in biological systems, including brain, and its reversal by the methionine sulfoxide reductase (Msr) system in various organisms during my postdoctoral training at Hoffman La-Roche (Nutley, NJ) and National Institutes of Health (under the supervision of the Dr. E. R. Stadtman, RIP). During my training, I have created several Msr type A knockout organisms starting with bacteria, yeast, and lastly of a mouse. All of these knockout strains exhibit higher sensitivity to oxidative stress and methionine oxidation. After appointed to a faculty position at the University of Kansas, I have developed a novel anti-MetO antibody (US Patent No. 8,409,824,B2) that has been successfully used by several researchers for the identification of MetO- proteins in various biological systems. My current research involves the use of MsrA knockout mouse as a model and the novel anti-MetO antibody to investigate the effect of MetO on protein function and cellular regulation. More specifically, the focus of my research is to elucidate the role of methionine oxidation and reduction in brain and the role of oxidative stress in neurological disorders and diseases. Publications and citations record:
Besides research, I enjoy painting on canvas, playing the piano and playing basketball in my free time.