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Effect of a guava and passion fruit juice on diabetic patients with hypertension

Galen College of Nursing
St. Petersburg, Florida
BiologyMedicineGrant: Public Health
Raised of $5,832 Goal
Ended on 2/04/17
Campaign Ended
  • $879
  • 16%
  • Finished
    on 2/04/17

About This Project

The incidence of cardiovascular diseases has increased 2-4 fold in patients with diabetes mellitus (DM) type 2. Recently, it was shown (APRIL, 2016 EDITION) that a juice of guava and passion fruit, cinnamon and flaxseed oil reduced blood pressure in hypertensive patients with diabetes mellitus type 2

This research project was designed to determine if this juice can also reduce high cholesterol and blood sugar in these patients.

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What is the context of this research?

Studies have shown that cinnamon, lycopene, and flaxseed can reduce systolic and diastolic blood pressure. Guava is high in lycopene and passion fruit is high in fiber which have been shown to reduce hypertension and blood sugar.

What is the significance of this project?

Hypertension and diabetes mellitus are highly prevalent conditions worldwide. HTN is the cause of at least 45% of deaths from heart disease, and 51% of deaths from stroke. Approximately 40% of adults over 25 years in the world were diagnosed with hypertension in 2008. HTN increases the likelihood of myocardial infarction, stroke and kidney failure

Drugs used for long-term treatment of HTN and DM generate a high cost to the health system, patients and their families, as well as the deterioration of their quality of life because of side effects.In 2012, 29.1 million Americans, or 9.3% of the population, had diabetes.

Thus, it is imperative to promote the search for new therapeutic agents such as nutraceuticals foods made from natural products that are derived from our diet and biodiversity

What are the goals of the project?

Hypothesis: the consumption of juice made of guava and passion fruit, compared with a placebo positively modifies blood parameters associated with HTN and DM, blood pressure, blood glucose, lipid profile, inflammatory markers and state antioxidant serum

If the funds are approved this study would begin on February 20, 2017.

This will be a double-blind study with a crossover design that will last for 8 weeks. Volunteers will be randomly assigned to consume either guava and passion fruit juice or placebo for 3 weeks. At the end of the first period (week 3), subjects are asked to come after a 12 hour overnight fasting to provide a blood sample, BP measurement and calculate the body mass index. This will be followed by a 2 week wash out period


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The University of Antioquia is contributing with the majority of the expenses, but the college where I work doesn't fund research of any type. The entire study has been on hold awaiting $5,832 from my end.

Personnel: $753

The personnel cost contributes to (stipend/payments) for a biotechnologist, lab technician, food engineer, nutritionist, and dietitian.

Material and reagents: $3666

The materials and reagents cost consists of all the tools necessary for biologically evaluating blood samples, purchasing and processing the juices and other laboratory supplies.

Technical services: $1413

The technical services cost consists of analysis of glucose, C-reactive protein and lipid profile that will allow us to (add short description). It will also cover microbial analysis and characterization of the beverage.

Endorsed by

All the ingrdients of the juice in question have been proven to modulate Cardiometabolic Risk. Increased intake of magnesium, potassium, flavonoids, carotenoids that are rich in the juice can decreased BPs, blood glucose and blood lipids.

Meet the Team

Adrian Isaza
Adrian Isaza


Galen College of Nursing
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Team Bio

The university of Antioquia conducted the first tracheal and esophageal transplant in the world so they are well respected for research and science. The team has extensive experience with the biochemical analysis of tropical fruit and Colombia is the first producer of passion fruit granadilla in the world.

Collaborators include Faber Jaramillo, a food engineer, Maria Maldonado, a doctor in health sciences, Cristina Gomez, a nutritionist, and Ana Ramos, a dietician

Adrian Isaza was born in New Jersey and raised in New York. When I was 20 years old I worked as a medical assistant for an orthopedic surgeon. Due to his lack of time, the doctor would typically eat fast food for lunch while he was driving which baffled me. Why would a wealthy doctor who knows about health eat fast food? A few years later, the question became why do patients take medications instead of following a diet? The answer to both questions became clear. it is a fast fix! This study poses an interesting question: If a glass of juice provided most of the nutrients you need to reduce hypertension, blood glucose and cholesterol would you drink it?

I am a chiropractic physician and a diplomate of the american clinical board of nutrition. I have published over a dozen papers and received two Donald P Kern awards in research. I have also been selected for presentation at the annual meeting of the American Public Health Association two consecutive times. Finally, I hold a bachelor degree in Spanish which has allowed me to communicate with researchers in Europe and South America

Additional Information





Project Backers

  • 20Backers
  • 16%Funded
  • $879Total Donations
  • $41.86Average Donation
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