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Mapping The Adolescent Brain: Stress, Cognitive Disorganization and Risk for Psychosis Belger, Aysenil.. University of North Carolina at Chapel Hill, 10 Nov 2014. Experiment
80 adolescents aged 9-16 years will be recruited from multiple sources to maximize variation in cognitive disorganization symptoms (measure described below). Recruitment and baseline assessments will be completed in years 1-3. Imaging will be conducted only at baseline, while 12 and 24 month follow-up evaluations during years 2-5 will consist of clinical, neurocognitive, and EEG measures. At each time point, participants will undergo clinical, neurocognitive and EEG testing.
Severity of CD will be measured at each time point through symptoms described below in detail. We will characterize the WMC construct by measuring neural activation and circuitry (fMRI), physiology (ERP and EEG), and behavior during an N-Back WM paradigm, and by using neurocognitive measures of WMC. To characterize the
ASR construct, we will measure neural activation of circuitry involved in regulating stress response and recovery, as well as physiological, molecular, behavioral, and self-report measures of HPA and ANS activity. Gonadal hormones (estrogen, testosterone, LH, and FSH) and Tanner puberty stage will be assessed at each time point to explore the effects of pubertal endocrine-mediated changes on stress regulation and CD
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