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Updates: Zika infection experiment on endometrial organoids

Hi Backers,

It has been rough few months here in Thailand with sudden new spikes in COVID cases. This has delayed some activities in the lab with us working in shifts and limitting the number of people around. Nevertheless, we are still working hard on the project.

Here's an exciting news!

Yes! We are able to infect our endometial organoids with zika virus. We even found that sex hormone levels may influent the virus' infectivity on the organoids. This is quite exciting that we are able to model Zika virus infection on the marternal side in the lab now. This is a good start for us to under stand the whole route of zika transmission from maternal to fetal compartments.

Here's a representative of our infected endometrial organoids. The endometrial cells are marked in red and Zika virus is marked in green. The blue objects are nuclei from each endometrial cells.

Stay tune for more exciting news.

-TW

3 comments

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  • N.D.Asha Wijegunawardana
    N.D.Asha Wijegunawardana
    Congratulations Tee! Please keep up the good work.
    Jun 30, 2021
  • Jackeline Alger
    Jackeline AlgerBacker
    Indeed exciting news facing challenging times! Congratulations Tee and team, wishing you to keep up!
    Jun 30, 2021
  • Janekrishna Kanatharana
    Janekrishna Kanatharana Backer
    Congratulations and looking forwards to hearing more exciting news in the near future!
    Jun 30, 2021

About This Project

As of mid-2019, 87 countries have had or still have Zika cases, underlining the importance of this infectious disease. Zika virus can infect the uterus and later infect the infant during pregnancy, causing neurodevelopmental defects at birth. This study will model Zika infection in the lab using uterine mini-organs. We hypothesize that our specific antibodies can neutralize Zika virus in the uterus and thus prevent later transmission from pregnant mother to unborn child.

Blast off!

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