jmarcosalarcon

One of the main questions in my laboratory is how experience modulates brain function. We began an investigation of how memory traces are represented in the organization and architecture of neuronal ensembles and synaptic circuits in the rodent hippocampus. We wish to provide a comprehensive understanding of how the brain changes with learned experiences by attempting to bridge the current gaps between neuronal ensemble activity, synaptic circuit function and molecular mechanisms that support memory. Malfunction of experience-dependent modulation of neuronal and synaptic circuits may be a prominent cause of neurological disorders. This research will lay the groundwork towards research on memory-associated modulation of neuronal circuits in mouse models of neurological disorders to gain insight into potential corrections of circuit function that could lead to treatments to improve cognitive outcome.

October 2020