About
My primary research focus is on discovery of new therapeutics for neglected tropical diseases, using a “repurposing” approach. We identify parasitic targets of importance that have been previously biochemically validated, with a further focus on those targets with human homologs that have been pursued in human drug discovery. My lab then prepares known ligands previously reported against the human homolog for assessment against the parasite target, and then pursue an optimization program from that starting point. Our lab focuses on repurposing phosphodiesterase inhibitors, kinase inhibitors, and histone deactylase inhibitors, and we are making great headway discovering new lead compounds for tropical diseases such as African sleeping sickness, Chagas disease, leishmaniasis, and malaria.
Joined
September 2013
