Building an Affordable Drug for Diabetic Wounds

Theresa L O'Keefe, Ph.D.

Mend Therapeutics

This project ended on:
5 May 2014
Mend Therapeutics is creating AFFORDABLE drugs for the World’s 371 Mill diabetics who don’t have health insurance. Diabetic complications are catastrophic and include non-healing wounds leading to amputation. We want to develop a protein for diabetic wounds that can be manufactured at low cost, an important step in creating an affordable drug. If all patients, irrespective of economic status, can afford medications, they have a brighter future.


Budget Overview

100% of our budget will be used to purchase supplies and conduct the necessary lab work to develop the low cost manufacturing process and produce small quantities of the two candidates. The project can be divided into 3 phase, each utilizing approximately 1/3 of the funding. The first phase involves creating the production system; the second phase involves determining the best protein purification process and the third phase involves manufacturing 5 mgs of each candidate to be used in functional assays.

Meet the Researcher


Dr. O’Keefe developed protein drugs for multiple companies include Pfizer, Critical Therapeutics, Millennium and LeukoSite. She also was Scientific Advisor for Pharma-Cycle, a company focused on cancer prevention in family members of patients undergoing chemotherapy. Dr. O’Keefe has > 15 years of biotech and pharma drug development experience as well as 10 years of academic research during which she co-authored tier 1 papers and co-invented > 30 patents and patent applications. Highlights include Millennium’s antibody expression system and Entyvio, Millennium’s antibody for Crohn’s and Inflammatory Bowel Disease currently under FDA review. She spent 6 years at the Medical Research Council Laboratory of Molecular Biology, Cambridge UK working with Drs. Michael Neuberger and Caesar Milstein (Nobel 1984). She co-founded Mend Therapeutics because she believes everyone should have access to the best therapeutics possible, irrespective of their ability to pay.

Endorsed by


Theresa O’Keefe is a creative and passionate scientist, with a long history of accomplishment in drug development. ...See more

Director of Drosophila Proteomics, Major University Medical School and Consultant, Biogen Idec


Mend Therapeutics has an innovative and patient centric approach to developing and delivering life saving medications...See more

Drug Development Expert


I am confident that Dr. O’Keefe and her colleagues at Mend Therapeutics will make a difference to the diabetic...See more

Professor, UMass Medical School


Mend Therapeutics

Diabetes is a world-wide disease with an ever growing personal, family and economic impact. The International Diabetes Federation (IDF) published Atlas to cover the statistics of the enormous burden diabetes puts on families around the world. The IDF is an umbrella organization of over 200 national diabetes associations in over 160 countries.

International Diabetes Federation Atlas 2014

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Project Backers

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