Targeted Drug Delivery by using Magnetic Nanoparticles

University of York
MedicinePhysics
DOI: 10.18258/0788
$3,010
Raised
100%
Funded on 8/06/13
Successfully Funded
  • $3,010
    pledged
  • 100%
    funded
  • Funded
    on 8/06/13

About This Project

What if we could use a novel approach for delivering currently injectable drugs to the body without syringes? What if we could destroy malignant cancer cells in difficult areas of the body that cannot yet be targeted? We are doing research to try to combine these into what we call the Nanject, in order to improve health care everywhere. For subtitles and multiple languages, please click here

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What is the context of this research?

The goal of this project is to develop a pharmaceutical Nano Patch which we call as the Nanject.This patch can be applied to the skin and will deliver specific amounts of target drugs where necessary. We are initially developing a patch for treating cancer, by injecting microscopic particles (or nanoparticles) into the bloodstream that can pinpoint, attach themselves to, and kill cancer cells. They are then naturally disposed by the body. This technology could potentially revolutionise health care and medicine and save millions of lives around the world as well as allow treatment of new types of cancer. We appreciate any and all support.

What is the significance of this project?

Even with current scientific advancements, we still have treatments such as chemotherapy aimed at killing cancerous cells, but during this process healthy cells are also destroyed. This can lead to death of the organism (a human in this case) before the actual death of the cancer. Targeted drug delivery aims to effectively target cancerous cells while not damaging the healthy cells. The potential applications behind this are huge, where we can diagnose and treat cancer in the most effective and efficient way with no side-effects. Atif has been working extensively on Nanoparticles, Spintronics and Targeted Drug Delivery by using Magnetic Nanoparticles so that we can target medicines to act towards specific areas in our body. The patch works by injecting tiny microscopic particles (nanoparticles) into the bloodstream that can pinpoint malignant cancer cells and attach themselves to them. Since the nanoparticles are magnetic this allows us to heat the particles up from outside the body to just the right temperature (controlled hyperthermia) to kill the cancer cells. After this the nanoparticles cool down again. They are then naturally disposed from the body, leaving other cells unharmed.

In addition to just delivering medicine and targeting cells, there is a pressing concern and need for an alternative to injections in the medical industry. The main reason some medicine is injected is that, when consumed orally, stomach acids destroy its active ingredients rendering it useless. Hence injections are used to send medicine directly into the body’s circulatory system. In order to do this a highly trained medical practitioner is required. A Nanject changes this as it has multiple invisible and painless microscopic syringes that plug into hair follicles on the human skin when it is applied, delivering the desired magnetic nanoparticles without any discomfort or pain. Upon success this can be used to deliver multiple different kinds of medicines as well in the future.

What are the goals of the project?

The funds will allow us to get Chemicals and Raw Materials. Everything else is being fuelled by our IT, programming, and nanotechnology expertise, the access we have to cutting-edge university clean rooms and other facilities, and above all our passion for making this a reality that could improve and allow many people’s future.

The project will approximately follow the following steps to achieve the final result:

Step 1: The project will start by using the already prepared nanoparticles and possibly some time to prepare a new set of samples using the same procedure.

Step 2: Examine the prepared nanoparticles under SEM/TEM (Scanning Electron Microsope / Transmission Electron Microscope) and proceed with coating of Gold, Proteins and different anti-bodies.

Step 3: Examine nanoparticles again after the coating process using the microscopes and inspect some magnetic and other properties that have changed.

Step 4: Get a thin Silicon wafer and grow microprojections or nanoprojections (microscopic needle-like tips). The microprojections can be made by using polystyrene nanobeads on top of a Gold plated Silicon substrate. The nanobeads will be placed at the surface and this substrate is kept in an evaporator where Iron is evaporated onto the surface of the substrate. In order to grow micro-nanoprojections, although I will refer the process described by Dr. Mark Kendall (who has recently been featured a lot in the media for his vaccine delivery system) et. al's journal publication "Fabrication of Micro-Nanoprojection Arrays and the Effect of Morphing on the Needle Profile"

but I have devised another method with the use of nanowires acting as the needles/micro-nanoprojectors. Also a possibility of having a Bio-MEMS (Microneedles) will be looked into which will allow us to have biosensors and also have microneedles instead of microprojections mentioned earlier.


Step 5: Depending on the success of step 4, the magnetic nanoparticles will be placed on top of the projections.

Step 6: Observe the properties to see how the overall Nanject performs and to see if there are any difficulties arising during the nanoparticle placement.

Budget

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The funds will be mainly used for Chemicals and Raw materials to prepare the nanoparticles and an early version of the Nanject. Cost of each is given as an approximate taken from Sigma Aldrich website and converted from British Pounds to US dollars.

Meet the Team

Atif Syed
Atif Syed
Student Researcher

Affiliates

Electronics and Nanotechnology Engineering, University of York, 2013
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Zakareya Hussein
Zakareya Hussein
Student Researcher

Affiliates

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Team Bio

My background is in Electronics and Nanotechnology Engineering and have been an amid programmer since I was 10 years old. I have always been into science and engineering by always questioning about everything! I have been involved in research in Swarm Robotics with a full time research job at York Centre for Complex Systems Analysis at University of York where I managed to make a Real Robotics Communication and Networking Model for Swarm Robots which in turn made me achieve a TRANSIT scholarship and became a TRANSIT scholar while pursuing my undergraduate degree. For about 2 years now, I have been working and researching on Nanoparticles, Biomedical Engineering, Material Science and Spintronics and the result of that leads to the current stage of my research.

More information can be found at my LinkedIn page.


Zakareya Hussein


Student Researcher

Background


My background is in Electronics Engineering with Nanotechnology at the University of York who have awarded me a Master’s degree in this subject. I have been interested in nanotechnology and its potential in health care and performance enhancement since I was 14 years old. I also have had the unfortunate luck of having been hospitalised many times. This is counterintuitively, however, also an advantage, as I have been through hospital systems in 3 different countries and know many of the differing national standards used around the world to treat the exact same conditions. I have taken courses on medicine in relation to electronics engineering as well as studied whatever I could in my free time, and have also been working on the implementation of a stroke rehabilitation system for my Master’s project. This shows my fascination and passion for the topic, which is what our joint project is all about.

Atif Syed

My background is in Electronics and Nanotechnology Engineering and have been an amid programmer since I was 10 years old. I have always been into science and engineering by always questioning about everything! I have been involved in research in Swarm Robotics with a full time research job at York Centre for Complex Systems Analysis at University of York where I managed to make a Real Robotics Communication and Networking Model for Swarm Robots which in turn made me achieve a TRANSIT scholarship and became a TRANSIT scholar while pursuing my undergraduate degree. For about 2 years now, I have been working and researching on Nanoparticles, Biomedical Engineering, Material Science and Spintronics and the result of that leads to the current stage of my research.

More information can be found at my LinkedIn page.


Zakareya Hussein


Student Researcher

Background


My background is in Electronics Engineering with Nanotechnology at the University of York who have awarded me a Master’s degree in this subject. I have been interested in nanotechnology and its potential in health care and performance enhancement since I was 14 years old. I also have had the unfortunate luck of having been hospitalised many times. This is counterintuitively, however, also an advantage, as I have been through hospital systems in 3 different countries and know many of the differing national standards used around the world to treat the exact same conditions. I have taken courses on medicine in relation to electronics engineering as well as studied whatever I could in my free time, and have also been working on the implementation of a stroke rehabilitation system for my Master’s project. This shows my fascination and passion for the topic, which is what our joint project is all about.

Zakareya Hussein

My background is in Electronics Engineering with Nanotechnology at the University of York who have awarded me a Master’s degree in this subject. I have been interested in nanotechnology and its potential in health care and performance enhancement since I was 14 years old. I also have had the unfortunate luck of having been hospitalised many times. This is counterintuitively, however, also an advantage, as I have been through hospital systems in 3 different countries and know many of the differing national standards used around the world to treat the exact same conditions. I have taken courses on medicine in relation to electronics engineering as well as studied whatever I could in my free time, and have also been working on the implementation of a stroke rehabilitation system for my Master’s project. This shows my fascination and passion for the topic, which is what our joint project is all about.

Additional Information







For any questions please contact either Atif or Zaki
For people who are interested in simulations, please follow the NanoHive project on SourceForge.
"I gotta stop somewhere, I will leave something for you to imagine" - Richard Feynman (1918-1988)



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