About This Project

Non-coding RNAs regulate levels of gene expression in cells, meaning that we now have a unique tool that allow us to regulate gene expression. Our plan is to use non-coding RNAs to help in our effort to treat cancer.

Ask the Scientists

What is the context of this research?

It was recently discovered that about 98% of the Human Genome codes for what are known as non-coding RNAs. Understanding and utilizing the function of these non-coding RNAs is the future of biological research. They have a wide range of regulatory functions in cells, from down regulating to activating the expression of thousands of genes. Thus far, however, there have been relatively few therapies developed using this technology because it is still in its infancy. We seek to change that.

The expression levels of non-coding RNAs have been directly correlated with the level of gene expression. Cancer has been demonstrated to have compromised non-coding RNA expression levels.

What is the significance of this project?

Non-invasive, effective cancer treatments are one of the most sought after therapies in scientific research. And for good reason; the World Cancer Day initiative estimates that cancer prematurely claims the lives of 4 million people each year. That's primarily due to the fact that currently there aren't any reasonable ways to isolate and treat cancer cells in the body. Cancer cells are nearly indistinguishable from healthy cells other than the fact that they have altered gene expression, and so are very difficult to target.

We are very excited to launch this project and combine older gene therapy techniques with the newer ones in ways that haven't yet been done to address this significant roadblock in the development of cancer therapies.

What are the goals of the project?

Begin investigating the potential of gene therapy for cancer treatment.