What can we do to prevent depression from coming back again?

University of Utrecht
Hackney, England
DOI: 10.18258/8878
Raised of $3,975 Goal
Funded on 6/14/17
Successfully Funded
  • $3,975
  • 100%
  • Funded
    on 6/14/17

About This Project

I am doing a systematic review to see what works to stop depression from returning again. Depression has a huge burden on society, people and families and this is particularly the case for recurrent depression. I want to look at the literature together with a team and estimate the effectiveness of interventions that help prevent relapse which can then result in recommendations for policy and practice.

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What is the context of this research?

Depression is prevalent and presents a large cost to society, communities and health services. For example, in 2008 the cost to NHS services is estimated at 1.7 billion and the cost to the economy due to lost employment is estimated at 7.5 billion and figures are expected to rise over the next decade (McCrone et al., 2008).

There are several approaches aimed at reducing the risk for relapse for people with high risk of relapse. However, people with depression can be reluctant to take antidepressants on a long-term basis (Keller, 2002) and other preventative approaches can be costly and subject to differential regional access (Rykroft-Malone et al., 2014).

What is the significance of this project?

There has to this date been one systematic evaluation looking at the effectiveness of low intensity preventative approaches for recurrent depression which was done in 2012. This study will undertake a systematic review and potential meta-analysis to evaluate the effectiveness for relapse prevention interventions in recurrent depression, it will provide an up to date view of the effectiveness of low-intensity approaches such as peer-support, self-management and online therapies on relapse prevention.

The findings will help GPs and commissioners to make evidence based decisions on commissioning services and referrals. It will also help empower people with recurrent depression to help identify new self-paced approaches to help prevent a relapse.

What are the goals of the project?

This is a systematic review. We will look at all the literature on the topic and then grade the literature on risk of bias and quality following Cochrane risk of bias assessments and GRADE assessments. After this we will study all approaches and assess what works and what does not work as much for people. We will also see, if we have enough data, whether we can analyse what works for whom and in which settings.

We have started with preliminary searches in January and aim to finish in September. An open access paper and lay summary will be published at the end of the project.


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The publishing fee will make sure I can publish in open access which means that it is freely available for others to look at the study without needing to pay.

The software will help to conduct the analysis. The support from other researchers is needed with some more technical statistical pieces of the analysis.

I'd like some funding for involving people with lived experience either directly or indirect as this will ensure I'm answering the questions that matter most and help give the review some practical application, the money will pay for their time and travel expenses.

Dissemination is hugely important and I would like to use some of the funding to organize an event with senior stakeholders to disseminate the findings and discuss impact for policy as well as published well-designed summaries of results.

As my supervisor is based in the Netherlands I do tend to make some ad-hoc trips hence the travel costs. Any underspent will be responsibly reallocated.

Endorsed by

It is my utmost pleasure to endorse the meta-analysis of Josefien Breedvelt and colleagues on relapse prevention for depression. This is a methodologically sound and timely research project. This project will provide an update on the latest systematic review and incorporate new research in this area. Ultimately, it will provide a platform for new avenues for research as well as clear recommendations for policy and best practices to ensure people get the best care and support available.

Project Timeline

Mar 15, 2017

Prepared PROSPERO template

Apr 30, 2017

Project Launched

May 06, 2017

Searches started

Jul 31, 2017

Title abstract screening

Aug 31, 2017

Full text screening

Meet the Team


Lab Notes

Nothing posted yet.

Project Backers

  • 10Backers
  • 100%Funded
  • $3,975Total Donations
  • $397.50Average Donation
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