Simon Jegan Porphy, Jegathese

Thank you :)

thank you

thank you

Yes, Indeed

Thank you and I am glad to see your comment.

Thank you please visit our website www.microsynbiotix.com

Thanks for the comment :) We are today a well establish start-up today please visit www.microsynbiotix.com

Thanks Willi Bosshard for your support. :)

Jim thanks for the advise but we are scientist with little or no interest in publicity. We want to work on a project that is useful and helps the community. Also, here in this project we are focusing on learning and understanding about microalgae as an expression system for producing therapeutic proteins.

Hello Jim Joyce thanks for showing interest in our project. Insulin is generally producing by using bacteria/yeast as an expression system. However, in both the cases as you had mentioned the Insulin protein requires separation from cellular components or biomass which would add additional cost. Also, Insulin is usually administered by the subcutaneous route, which significantly reduces morbidity and mortality. However, many patients fail to achieve long-term glycemic control which result in obesity and other illness . However, Oral Insulin delivery is considered to have high patient compliance. In our study we are trying to understand if the insulin protein can be accumulated within the microalgae biomass so that it could be used for oral insulin delivery. The advantage of using microalgae is that it has a rigid cell wall which would help provide protection against harsh acidic conditions in the stomach and other enzymatic degradation. As a result, the Insulin gets absorbed in the small intestine and maintain better glucose haemostasis. Thus, recombinant microalgae expression system could possibly play a pivotal role in the development of an oral insulin delivery method and reduce the cost of Insulin. If you require references or detailed explanation please don't hesitate to contact us.

Thanks Sergey