Hookworms affect the lives of more than 400,000,000 men, women and children around the world. The most effective drugs available today work only some of the time, on some of the worms. In fact, these drugs were originally developed for veterinary medicine, not for human treatment. Our goal at Wormfree World Institute, a 501(c)(3) not-for-profit research center is to discover and develop urgently-needed drugs to free children from intestinal roundworms. We strive for a wormfree world, which we can accomplish with your help!
You can't always tell by looking at them. The boys and girls in the picture below are infected with parasites. Hookworms stunt their growth, fog their brains, and weaken their immune systems, making them more susceptible to HIV, TB and other infectious diseases. The number of people affected is greater than the combined populations of the United States and Canada. We believe that the cure for this disease is within our reach, and deserves our immediate attention.
Using high throughput screening, we will screen 1,000 promising drug compounds directly on human intestinal hookworms- not on worms found in farm animals. Our bench scientist works in a research space in San Diego, and we have assembled everything we need to begin the first phase of the drug discovery process. Screens will be carried out in a 96-well format containing hookworms, experimental compound, and liquid hookworm medium. The impact of experimental compounds will be assessed based on parasite motility, size, and coloration. Post-screening, we anticipate designing an in-depth drug development effort around our best lead compound(s).
100% of our budget will be used in the lab to test potential cure compounds.