Anti-Phospholipid Syndrome (APS) is an autoimmune disease in which certain antibodies cause blood clotting. These antibodies are an important cause of spontaneous miscarriage in women aged 20-50 years. There is no effective treatment for APS. Our project will test whether small peptides we have discovered, can block the activity of these antibodies. Positive results from these experiments will support further development of the peptides as a new therapy for APS.