rcoberly

Good luck! Happy to contribute again, now & in the future. Really hope you can keep your team together and extend knowledge in this area. And a related matter, see also https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983076/#!po=98.3871 This is a VA study, "Modified Atkins diet in advanced malignancies - final results of a safety and feasibility trial within the Veterans Affairs Pittsburgh Healthcare System", following 17 human patients with advanced malignancies, on a KD for at least 16 weeks, extended out to 121 weeks in one case.

Really appreciate the detailed response.

Really appreciate the detailed responses.

ACA & BHB are a redox couple. so? Perfuse the cell cultures w/ ketone bodies separately & also in varying proportions from oxidized to reduced. In western diets, high fed-state reduction pressure is likely a common systemic milieau.

Good luck, may this proceed as planned. BTW, http://www.ncbi.nlm.nih.gov/pubmed/26990457 is interesting. LAC/HCO3 in a tumor model, with MRS used to show in vivo a shift from glycolytic toward ox phos metabolism under a anti-angiogenic therapy.