Eugene J Fine

Eugene J Fine

eugene.fine@einstein.yu.edu

Albert Einstein College of Medicine/Montefiore Medical Center/ SUNY Downstate Medical Center

Professor of Radiology (Nuclear Medicine)

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Published on Feb 24, 2021

New results part I. Animal studies

We've had some difficulties getting these results posted, but we can try again here. It's now February of 2021 and there's much to report. We've published a mouse study (in PLOS ONE) entitled: "The...

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Published on Jul 16, 2018

Almost forgot some news

A lovely human and humane documentary out of Australia called "The Magic Pill" has been available on Netflix. We should have mentioned it earlier, but better now than to have forgotten completely.T...

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Published on Jul 09, 2018

Things are finally moving ahead

Things are finally moving ahead1) In our last lab note, many months ago, we were expecting our human trial to begin very shortly. We finally began our human trial in JUNE 2018, more than 9 months a...

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Published on Sep 13, 2017

What's happened since we obtained funding?

What's happened since we obtained funding?In case you missed it, we sent a message several months ago that, as an unexpected bonus from our Experiment campaign and your donations, we found an angel...

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Published on Jun 14, 2017

We are very excited to inform you

We want all of you to be aware that we have experienced a breakthrough in support for our research which happened because of you.A philanthropic donor found us on the Experiment.com site. He has si...

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Published on Jan 04, 2017

What you've done for us--Our next steps

Anna and Gene are in front of the newly obtained Microplate reader (blue and white, right behind the diskette that Anna's holding). This was purchased with your donations and now ma...

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Published on Sep 30, 2016

Where we go from here! (We promised)

We've been enormously gratified by the response of thousands of people to the idea that we may be able to influence our body's metabolism in the direction of improved health by restricting the amo...

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Published on Sep 27, 2016

Thank you AGAIN! So where do we go from here?

So many of you have told us that you feel part of theresearch process. We have felt the same way. We've had to pinch ourselves when we've contrasted this experience to writing a grant toan imperson...

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Published on Sep 23, 2016

What did Dr. Owen and Dr. Cahill do? Why was this so important?

In the late 1960's, Drs. Oliver Owen and George Cahill did one of the fundamental experiments in brain metabolism. (Mea culpa-- I identified Dr. Owen as Robert Owen mistakenly, now corrected). They...

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Dear Rutvi, I'm sorry for my very delayed response. Some notes from viewers never made it to my email box when my email changed. Thank your for your continued interest. Gene and Richard
Sep 16, 2021
Can low carbohydrate ketogenic diets inhibit cancers?
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Thank you for your comment. My own preference is for low carbohydrate diets (i.e. less than 100 grams of starches and sugars a day). I can stay strictly ketogenic (say less than 40 grams/day) for periods of a few months at a time, but I find it's difficult for me to keep that going and I revert to less than 100 grams. I can stick with that. Overall, I think it's difficult to make useful dietary recommendations for weight loss and specific areas for reduction. In general, we're already eating what we like or we wouldn't be eating it. So changing to another diet is, by definition, changing to something we don't like as well. That's hard to sustain. So I don't fully understand why I could change to a low carb diet from the much higher carb intake that I had been consuming (based on the low fat recommendations that I now realize were completely wrong), but I have a guess. I don't believe much in 'will power' as a useful concept simply because it doesn't work for most people. So my guess for myself is that I've always liked a sufficiently wide variety of foods that I was able to change the distribution of foods that I ate to other foods that I also liked. So I was simply lucky, as I never felt deprived. I was never overweight, but for my frame I carried more fat weight than I wanted. Over a period of about 10 years, I lost about 30 pounds and have remained at a generally stable weight for another 10 years. I don't know if the above helps at all. If you want to explore low carbohydrate and/or stricter ketogenic diets, there are many fine books. One is by Richard Feinman, my colleague, friend, and co-author of this Experiment. com. Other good books on the topic are by other colleagues and friends, Jeff Volek and Stephen Phinney, both experts as well. You can look them up on any book website. Best, Gene
Jul 24, 2021
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Hi Viviana, Your comment about estrogen receptor expression seems to have been cut off, so kindly re-enter it for me to be able to respond. Gene
Jul 24, 2021
Can low carbohydrate ketogenic diets inhibit cancers?
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Merci bien. Nous l'espère aussi. Gene et Richard
Jul 18, 2021
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Jennifer, And thank your for your interest and your comment. Gene and Richard
Apr 29, 2021
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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That's very true. Our recent article in PLOS One in mice with breast cancer metastastic to lung tested a ketogenic diet (KD) alone vs, standard diet (SD) alone, as well as the same diets with two different doses of rapamycin. Rapamycin can be toxic in humans (though it isn't in mice). And the KD animals at lower doses (or no) rapamycin had as long or longer survival than the SD animals at the next higher rapamycin dose. We believe that if this translates to humans (and that must be tried experimentally) it will apply to other toxic drugs as well. And the implications would be improved longevity for patients, as well as improved quality of life during that longer lifespan, all because the dose of the toxic drug would be lower.
Apr 29, 2021
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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This is true, but the point is that other cancers may respond. It's important to determine which cancers are responsive to a particular therapy in advance of the treatment. In breast cancer, for example, the biopsy specimen can provide information about the expression of estrogen receptors (ERs) on the cancer cells. If they express ERs, the cancer is likely to respond well to ER blockers, such as Tamoxifen. Tamoxifen has revolutionized the treatment of breast cancer for many women. I hope this helps. Gene and Richard.
Apr 01, 2021
Can low carbohydrate ketogenic diets inhibit cancers?
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Yes, it's possible, but the point is that it's also possible for a keto diet to help. What's most important is to determine in advance whether the tumor is likely to respond to the keto diet. This is analogous to breast cancer treatment, where estrogen receptor expression, in advance (from biopsy material), determines whether to use estrogen receptor blockers, such as tamoxifen. I hope this helps. Gene and Richard
Apr 01, 2021
Can low carbohydrate ketogenic diets inhibit cancers?
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Hi Cindy, Thank you so much for your comment and your support. We hope that our results will translate to humans, but that's always the big question. Mice and humans are mammals but that only gets us so far. Gene and Richard
Mar 07, 2021
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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We agree completely and believe that keeping insulin low speaks strongly to prevention. Thanks so much for you comments and support. Gene and Richard
Mar 07, 2021
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Thank you so much. I tried to link the study but it didn't work. I wrote to Experiment to ask them about it, but so far they haven't been able to fix it. I don't get it, and it's definitely frustrating. Gene and Richard
Feb 25, 2021
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Than you Rod for staying with us. The research has proceeded slower than we'd hoped, partly due to COVID. Best, Gene and Richard
Feb 25, 2021
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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