researcher
Eugene J Fine

Eugene J Fine

eugene.fine@einstein.yu.edu

Albert Einstein College of Medicine/Montefiore Medical Center/ SUNY Downstate Medical Center

Professor of Radiology (Nuclear Medicine)

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Published on Sep 13, 2017

What's happened since we obtained funding?

What's happened since we obtained funding?In case you missed it, we sent a message several months ago that, as an unexpected bonus from our Experiment campaign and your donations, we found an angel...

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Published on Jun 14, 2017

We are very excited to inform you

We want all of you to be aware that we have experienced a breakthrough in support for our research which happened because of you.A philanthropic donor found us on the Experiment.com site. He has si...

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Published on Jan 04, 2017

What you've done for us--Our next steps

Anna and Gene are in front of the newly obtained Microplate reader (blue and white, right behind the diskette that Anna's holding). This was purchased with your donations and now ma...

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Published on Sep 30, 2016

Where we go from here! (We promised)

We've been enormously gratified by the response of thousands of people to the idea that we may be able to influence our body's metabolism in the direction of improved health by restricting the amo...

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Published on Sep 27, 2016

Thank you AGAIN! So where do we go from here?

So many of you have told us that you feel part of theresearch process. We have felt the same way. We've had to pinch ourselves when we've contrasted this experience to writing a grant toan imperson...

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Published on Sep 23, 2016

What did Dr. Owen and Dr. Cahill do? Why was this so important?

In the late 1960's, Drs. Oliver Owen and George Cahill did one of the fundamental experiments in brain metabolism. (Mea culpa-- I identified Dr. Owen as Robert Owen mistakenly, now corrected). They...

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Published on Sep 23, 2016

Carbohydrate Restriction and Evolution: Does our dietary ancestry give clues about its health value?

There's plausible evidence that limited carbohydrate intake characterized much of human evolution. First of all, modern man, or homo sapiens, has been around for about 200,000 years, whereas agricu...

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Published on Sep 20, 2016

Please note new stretch goals and extra time to achieve them!!

Our initial goal has been reached and that means continuing our cell culture research program for a year. Thank you again! We accepted the offer  for an extension by Experiment.com because we need ...

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Published on Sep 20, 2016

THANK YOU!!

To all,Thanks to all of you we have reached our target of $50,000!! We are awed by the number of like-minded individuals from across the globe and around the world who have rallied to support our r...

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Published on Sep 17, 2016

The relation of cell culture data to human studies (4)

There's one specific aspect of our cell culture data that makes it resemble the in vivo human situation: In people on a strict low carbohydrate diet (very compliant), blood insulin concentrations w...

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Published on Sep 14, 2016

The relation of cell culture studies to human studies (3)

We just discussed that Petri dishes used to test bacterial sensitivities don't always correctly predict antibiotic effectiveness in vivo. A general explanation goes something like this: the in vivo...

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Published on Sep 14, 2016

The relation of cell culture results to human studies (2)

I mentioned in the last lab note that cells growing in Petri dishes don't always behave the same as cells growing in a living organism. And this is true. Take bacteria, the first example I mentione...

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Hi Celeste, The trial will last 1 1/2 to 2 years. From the point of view of wonderful contributors such as yourself we won't be seeing or reporting results until after all recruitment is completed.(65 patients in total at about 3 per month will take almost two years) and then we will do all the blood and tissue measurements in one batch to insure they are all processed exactly the same way. So this may be frustrating or disappointing for you, but we are determined to insure the most reliable and accurate results. However I do believe that we will be able to report interim results of our important ancillary experiments that are also now funded--namely our animal studies in which we couple diet with anti-cancer drugs, and our cell culture studies. We deeply appreciate all of your continued interest and support. Thank you again. Gene and Richard
Aug 12, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Dear Mark, Thank you so much for your enthusiastic support and offer of assistance. We don't have an immediate mechanism to integrate you into our program, but that's not to say that it can't be done. I'm on vacation until the end of July (first extended break since I was 20), but we can be in touch on my return in August. Best would be to give me your preferred contact information and I will connect with you in early August. Best, Gene and Richard
Jul 13, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Dear Gloria, I am so sorry about your diagnosis. Our trial is approved by our institution for certain patients with newly diagnosed breast cancer, only. It is not even a treatment trial as it only examines what happens to the cancer tissue between the biopsy and the surgical removal (about 2-4 weeks later). 45 of the patients will go on a ketogenic diet and 20 on a low fat diet of similar calorie content. We don't have any flexibility in these trials because human research studies are very carefully regulated both to prevent abuses and to maximize the gain in scientific knowledge. I wish I could do more. Gene
Jun 16, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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We're fully staffed, so the stage of assembling our team is that of training our hired members to perform their necessary functions. Thank you for your interest.
Jun 15, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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I'm glad to be able to contribute to this project. It tackles such a difficult medical problem that threatens so many.
Mar 17, 2017
Protecting the brain from Alzheimer's disease by enhancing natural survival tools.
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We're thrilled that more than 500 contributors from around the world (truly from 6 continents) made our current work possible. We couldn't continue this without your help. Gene and Richard
Jan 04, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Hi Jodie, I thought I responded but can't see my response on the Experiment website, so I apologize if this is redundant. First, we're currently re-studying all 10 of our cell lines (7 cancers and 3 fibroblast controls) using more modern methodology as well as adding important assays we didn't do the first time around--metabolomics, ROS assays, etc. The repeat studies for metabolomics are in process now and should be completed maybe in 6 weeks, give or take. At that point I beleeve we're freezing enough cells that we're growing now so that we can start assaying for ROS too. So in about 2-3 months we'll see how the data looks and may be in position to write it all up and submit for publication. (It won't be appropriate to publish our results here on Experiment). If we're fortunate enough to get accepted right away we can then have our results posted either here on Experiment or elsewhere (our Nutrition & Metabolism website, for example). Meanwhile, we're enriching the N & M website by posting all text and Lab Notes from this Experiment. And we're also adding links to videos of talks we have given on ketogenic diets. The N & M website is in the process of re-construction, so I don't know the exact time frame for these to appear, but I'm hoping it will be a matter of just a few weeks. Thanks so much for your interest. I'm eager for these updates to move ahead too!! Gene and Richard
Nov 17, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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HI Naomi, It's wonderful that you do this. I do believe that our research goals align with yours very well. Why don't you contact me directly at my email. We should probably talk. eugene.fine@einstein.yu.edu. Gene
Nov 02, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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No, thank You for your interest. Richard and I are in the midst of grant proposal writing, but expect to be more free by the end of this week. Thereafter it's our goal to enrich our website as well as Richard's blog (Feinman the Other). Richard has embraced social media and the blogosphere so I mostly depend on him to get our work posted on the net. Gene and Richard
Oct 24, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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As Richard also noted, we believe that we may have a way to engage the pharmaceutical industry. If we can improve outcomes at lower toxicity, everyone wins. I'm not in the business of endorsing nor castigating Big Pharma. It's not in my interest to do either and if I dare suggest it, it shouldn't be in anyone's specific interest to do so either. Drugs are both wonderful and also terrible, but it's our (all of our) jobs to get the best from drugs as well as any other tools we have (e.g. diet). Think of talking with a drug company in the following way: "This diet is going to improve your drug's performance by improving its efficacy and reducing its toxicity. It will make your drug look good." Everyone wins. Now I don't disagree with you that the above approach may not immediately impress anyone in the pharmaceutical industry. But I do sustain the hope that eventually this sound idea will prevail.
Sep 30, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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I have heard of the same study and will look into it. I'm quite interested in this myself as there are a few studies that have shown improved cognitive function in people with mild cognitive dementia and early Alzheimer's. These studies have been small. If these findings are confirmed in larger trials, the implications would be astonishing! The best that drugs today for MCI and early AD can claim is that they slow the progression of the disease. There's nothing available that results in cognitive improvement.
Sep 30, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Thank you. We will look into this. Gene
Sep 30, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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