Eugene J Fine

Eugene J Fine

eugene.fine@einstein.yu.edu

Albert Einstein College of Medicine/Montefiore Medical Center/ SUNY Downstate Medical Center

Professor of Radiology (Nuclear Medicine)

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Published on Jul 16, 2018

Almost forgot some news

A lovely human and humane documentary out of Australia called "The Magic Pill" has been available on Netflix. We should have mentioned it earlier, but better now than to have forgotten completely.T...

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Published on Jul 09, 2018

Things are finally moving ahead

Things are finally moving ahead1) In our last lab note, many months ago, we were expecting our human trial to begin very shortly. We finally began our human trial in JUNE 2018, more than 9 months a...

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Published on Sep 13, 2017

What's happened since we obtained funding?

What's happened since we obtained funding?In case you missed it, we sent a message several months ago that, as an unexpected bonus from our Experiment campaign and your donations, we found an angel...

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Published on Jun 14, 2017

We are very excited to inform you

We want all of you to be aware that we have experienced a breakthrough in support for our research which happened because of you.A philanthropic donor found us on the Experiment.com site. He has si...

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Published on Jan 04, 2017

What you've done for us--Our next steps

Anna and Gene are in front of the newly obtained Microplate reader (blue and white, right behind the diskette that Anna's holding). This was purchased with your donations and now ma...

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Published on Sep 30, 2016

Where we go from here! (We promised)

We've been enormously gratified by the response of thousands of people to the idea that we may be able to influence our body's metabolism in the direction of improved health by restricting the amo...

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Published on Sep 27, 2016

Thank you AGAIN! So where do we go from here?

So many of you have told us that you feel part of theresearch process. We have felt the same way. We've had to pinch ourselves when we've contrasted this experience to writing a grant toan imperson...

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Published on Sep 23, 2016

What did Dr. Owen and Dr. Cahill do? Why was this so important?

In the late 1960's, Drs. Oliver Owen and George Cahill did one of the fundamental experiments in brain metabolism. (Mea culpa-- I identified Dr. Owen as Robert Owen mistakenly, now corrected). They...

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Published on Sep 23, 2016

Carbohydrate Restriction and Evolution: Does our dietary ancestry give clues about its health value?

There's plausible evidence that limited carbohydrate intake characterized much of human evolution. First of all, modern man, or homo sapiens, has been around for about 200,000 years, whereas agricu...

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Thanks for the additional remarks Steve. We're doing a ketogenic diet cancer study right now, although it can't be described as zero carbohydrates. I'm not sure that even full carnivore is zero carbs in view of muscle glycogen, but I need to refresh my knowledge of the glycogen content in red meat and whether it withstands cooking. Gene and Richard
Sep 24, 2018
Can low carbohydrate ketogenic diets inhibit cancers?
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Dear Steve, That is outstanding news! Interestingly, I suspect that you may have been responsive to a strict ketogenic diet because your prostate cancer was so aggressive. By this I mean that it was so PET avid. Many less aggressive prostate cancers are not glycolytic/glucose-dependent, I.e. can metabolize fatty acids and ketone bodies as fuels. In any event, we wish you continued good health and thank you very much for sharing your news with us!! Best, Gene and Richard
Sep 24, 2018
Can low carbohydrate ketogenic diets inhibit cancers?
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Dear Lech, Thanks so much for your continued interest. We've had difficulties starting our human trial in losing one food vendor, finding another but only from overseas, as we then needed USDA approval to import the foods because we couldn't find a ketogenic food vendor in the U.S. The irony to me was that it would have been easier to do a drug trial. However, we've straightened all these things out and we're expecting a food delivery actually within a week, and can likely start our human trial within another week. So we're eager to start the human trial. The animal trial has also been held up by food issues. We will have more news in about a week on the cell studies. Best, Gene
Mar 11, 2018
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Hi Celeste, The trial will last 1 1/2 to 2 years. From the point of view of wonderful contributors such as yourself we won't be seeing or reporting results until after all recruitment is completed.(65 patients in total at about 3 per month will take almost two years) and then we will do all the blood and tissue measurements in one batch to insure they are all processed exactly the same way. So this may be frustrating or disappointing for you, but we are determined to insure the most reliable and accurate results. However I do believe that we will be able to report interim results of our important ancillary experiments that are also now funded--namely our animal studies in which we couple diet with anti-cancer drugs, and our cell culture studies. We deeply appreciate all of your continued interest and support. Thank you again. Gene and Richard
Aug 12, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Dear Mark, Thank you so much for your enthusiastic support and offer of assistance. We don't have an immediate mechanism to integrate you into our program, but that's not to say that it can't be done. I'm on vacation until the end of July (first extended break since I was 20), but we can be in touch on my return in August. Best would be to give me your preferred contact information and I will connect with you in early August. Best, Gene and Richard
Jul 13, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Dear Gloria, I am so sorry about your diagnosis. Our trial is approved by our institution for certain patients with newly diagnosed breast cancer, only. It is not even a treatment trial as it only examines what happens to the cancer tissue between the biopsy and the surgical removal (about 2-4 weeks later). 45 of the patients will go on a ketogenic diet and 20 on a low fat diet of similar calorie content. We don't have any flexibility in these trials because human research studies are very carefully regulated both to prevent abuses and to maximize the gain in scientific knowledge. I wish I could do more. Gene
Jun 16, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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We're fully staffed, so the stage of assembling our team is that of training our hired members to perform their necessary functions. Thank you for your interest.
Jun 15, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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I'm glad to be able to contribute to this project. It tackles such a difficult medical problem that threatens so many.
Mar 17, 2017
Protecting the brain from Alzheimer's disease by enhancing natural survival tools.
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We're thrilled that more than 500 contributors from around the world (truly from 6 continents) made our current work possible. We couldn't continue this without your help. Gene and Richard
Jan 04, 2017
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Hi Jodie, I thought I responded but can't see my response on the Experiment website, so I apologize if this is redundant. First, we're currently re-studying all 10 of our cell lines (7 cancers and 3 fibroblast controls) using more modern methodology as well as adding important assays we didn't do the first time around--metabolomics, ROS assays, etc. The repeat studies for metabolomics are in process now and should be completed maybe in 6 weeks, give or take. At that point I beleeve we're freezing enough cells that we're growing now so that we can start assaying for ROS too. So in about 2-3 months we'll see how the data looks and may be in position to write it all up and submit for publication. (It won't be appropriate to publish our results here on Experiment). If we're fortunate enough to get accepted right away we can then have our results posted either here on Experiment or elsewhere (our Nutrition & Metabolism website, for example). Meanwhile, we're enriching the N & M website by posting all text and Lab Notes from this Experiment. And we're also adding links to videos of talks we have given on ketogenic diets. The N & M website is in the process of re-construction, so I don't know the exact time frame for these to appear, but I'm hoping it will be a matter of just a few weeks. Thanks so much for your interest. I'm eager for these updates to move ahead too!! Gene and Richard
Nov 17, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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HI Naomi, It's wonderful that you do this. I do believe that our research goals align with yours very well. Why don't you contact me directly at my email. We should probably talk. eugene.fine@einstein.yu.edu. Gene
Nov 02, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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No, thank You for your interest. Richard and I are in the midst of grant proposal writing, but expect to be more free by the end of this week. Thereafter it's our goal to enrich our website as well as Richard's blog (Feinman the Other). Richard has embraced social media and the blogosphere so I mostly depend on him to get our work posted on the net. Gene and Richard
Oct 24, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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