researcher
Richard D Feinman

Richard D Feinman

SUNY Downstate Medical Center/Nutrition and Metabolism Society

Professor of Cell Biology

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Haven't backed any projects yet! 

My recollection is that Cahill told you personally that he knew about the misinterpretation But that he felt it was too late to fix. Is that accurate memory?
Sep 24, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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I think that our big problem rests with academic medicine and the NIH and other public and private health agencies which are very conservative and very slow to change. One of the likely outcomes of our research is that a ketogenic diet may be a valuable adjunct to pharmacology allowing drugs to be used at much lower doses thereby reducing side-effects and toxicity. We need the help but, in the end, we may be helping big pharma. (This is not our main goal -- they have no trouble finding a way to make a profit). We are also trying to get them to help us although they are also very conservative on what they like to fund. We are, again, very grateful for the backing from this community.
Sep 23, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Explaining the diagram, Part II. GLYCOLYSIS glucose ---------> pyruvate. Pyruvate can be converted to many things. Some cells -- many bacteria and other microorganisms, rapidly exercising muscle cells and red blood cells -- use only glycolysis for energy. Those cells convert pyruvate to other things like alcohol or lactic acid (fermenting bacteria produce ethanol and lactic acid bacteria are the cultures in yoghurt). Such cells are said to have an anaerobic energy metabolism because glycolysis does not require oxygen. Looking ahead, many cancer cells are said to be "glycolytic" because they only use glycolysis even in the presence of oxygen while the normal cells from which they derive run glycolysis but further process the glycolysis using oxygen. Of importance, the Warburg effect refers to Otto Warburg's observation that cancer cells were producing lactic acid. One of the products that aerobic (oxygen-requiring) cells produce is acetyl-CoA. (You can just remember it as a name or, if you took freshman chemistry, you may recognize it as a derivative of acetic acid). Acetyl-CoA is the substrate for oxidative metabolism. A combination of processes (Krebs cycle, electron transport) referred to as respiration is where most energy is obtained in most human cells and requires oxygen. Details of respiration to be discussed in part III but the take-home message here is that the compound acetyl-CoA is the big player in oxidative metabolism. It is not only produced from glycolysis but also (primarily if you are on a low-carb diet) from fat in a process called beta-oxidation, and also from some amino acids from protein. Ketone bodies also produce acetyl-CoA. Ketone bodies are made in the liver and provide acetyl-CoA to other tissues. Part III will explain why and how. Figure summarizing info so far: https://dl.dropboxusercontent.com/u/37202414/EXPERIMENT-II_SEPT_23.png
Sep 23, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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The diagram was, of course, technical, but I think the take home message is important so I will give a basic explanation (Biochemistry 101). There are chemical names but I don't discuss the chemistry so you can just learn them as names. Part I. All cells, all organisms, use the same mechanism to process glucose. The process is called glycolysis. The name tells you that it is the lysis (breaking) of glucose. Glucose is a six carbon compound and the lysis gives you two molecules of a three carbon compound called pyruvic acid. (In biochemistry acids are indiscriminately called by the acid name or by an "ate" name. "Pyruvate" and "pyruvic acid" are two names for the same molecule.) so: glucose ---------> pyruvate is the process of glycolysis ( although it has many steps). Part II when i get to real computer.
Sep 22, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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I would add an optimistic note to Gene's comment. We have ignorance on our side. What I mean is that the subject is so poorly investigated and the potential is very clear. We think that we know how to ask the right questions we are confident that we will get something of value. And, again, grateful for the backing.
Sep 21, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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Jennifer, I would add to Gene's comment that one of our goals is to see whether we can develop ketogenic diets as a therapeutic adjunct so that chemo or other modalities can be carried out at less toxic levels.
Sep 21, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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I would add to Gene's comments that researching this question and seeing the lack of information show us just how little information there is on diet at all in cancer therapy. There is some meaning in this in that ketogenic diets are the most reasonable approach and this was not on anybody's radar. That is why we think that results with cancer may actually point the way to better therapy for diabetes and other metabolic disease.
Sep 06, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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I would not say 'never.' One of the great promises in the ketogenic approach is that it can be used as an adjunct for drugs which may target cellular elements but which are too toxic or have very serious side-effects. We think, for example, that based on the results with diabetes where there is substantial reduction in need for medication on low-carb diets, that all drug studies should have two drug arms with and with carbohydrate reduction. We think this would make the drugs look better and help the patient. This is in a drug company's interest. Experience tells us that they will be slow to see the value in this -- were are trying to obtain funding for such studies and it is slow enough -- but I think that we can do better than 'never.'
Sep 06, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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We are really grateful and, of course, the research is our main goal but it suddenly hit us that these donations and comments constitute an antidote to all the BS that we have to tolerate.
Sep 03, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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I would add to Gene's comment that like many health agencies, the Budwig protocol has it all figured out. We don't know the answer. Research involves asking a question that will give you a productive answer however it comes out. As Gene mentioned, the importance of ketosis and insulin reduction and the general picture of many cancers as cells of limited metabolic flexibility, means that we can refine our understanding. If we find, for example, that particular cancer cells are showing the classic Warburg effect because they are over expressing one or another GLUT channels, that is, are better ability to take up glucose, we can target that protein while simultaneously making ketone bodies available for normal cells. Because we are approaching things from basic science and because, in some sense, we are coming into a system that, for whatever reason, has been under-investigated we have to ask precisely how patients respond. If you are tied to a particular protocol, you likely only get a yes or no answer and, in cancer, medicine has not been coming up with a lot of yes.
Sep 01, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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We are grateful for you contribution. It is an important project.
Aug 10, 2016
Part 2: Can low carbohydrate ketogenic diets inhibit cancers?
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We already have some results as described in some of the text here but there are several answers as to why they haven't been done before, the main one being that we humans don't always see the obvious and we are subject to our limited experience. What is it about ketone bodies? We learn about it in the context of starvation and untreated type 1 diabetes which doesn't happen much and when it does happen is threatening. But how much of the time were our ancestors hunting and gathering and how much starving or at least on really extended fasts? The idea that the biochemistry of ketone body metabolism was as fundamental to our evolution as glycolysis and the TCA cycle is not something that we think about a lot or, for some of us, is a thing that sits in the back of our mind for years until we suddenly realize it is a really big deal. Took me way longer than some people. There is also the fact that medicine which exerts a major influence in the research is about drugs. The mind set of medicine is that drugs are about science and and diet is about "lifestyle" which is not serious. Thanks for your backing and we think your optimism is justified. It is precisely because we think that it is sure to be fruitful that we are persisting in the face of limited support from the usual sources of funding. We don't know the answer but I always tell students is that the best research project is one where you know you'll get definite results.
May 01, 2016
Can low carbohydrate ketogenic diets inhibit cancers?
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