Dr. Elizabeth Iorns

Dr. Elizabeth Iorns

Palo Alto, CA

Education:
Postdoctoral Associate, Cancer Biology; University of Miami
Ph.D., Cancer Biology; The Institute of Cancer Research, University of London
B.Sc (Hons), Biomedical Science; University of Auckland

Co-Founder & CEO at Science Exchange, Science Exchange

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Published on Feb 22, 2014

Latest update

I haven't posted an update for several months so I wanted to let you know that we are still working on this project and are trying several different methods to obtain Brca1 mutant pups. First, the ...

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Published on Nov 30, 2013

Failure to breed

You may remember from my last update that we had managed to obtain one Brca1 heterozygous mutant pup, which we planned to breed to get enough mice for the PARP inhibitor experiment. Unfortunately I...

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Published on Aug 06, 2013

We have a Brca1 mutant heterozygote!

Dr. Cowley gave me another update on the status of the breeding of the Brca1 mutant mice today: "I just wanted to let you know that 1 of the 4 surviving pups is a Brca1 heterozygote female. We hav...

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Published on Jul 11, 2013

The pups are born!

Dr. Cowley gave me an update on the status of the breeding today: "We had 5 pups born Tuesday from the second round of Brca1 transfers. One pup died, but the other 4 are doing well. Hopefully we w...

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Published on Jul 03, 2013

Pups update

Last month I wrote about the problem we had obtaining viable Brca1 mutant pups (https://www.microryza.com/projects/can-we-prevent-the-transmission-of-brca-mutations/updates/262/). Unfortunately o...

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Published on May 23, 2013

Pups

Several weeks ago we obtained frozen embryos from the NCI to breed our Brca1 null mutated mice for the study: http://mouse.ncifcrf.gov/available_details.asp?ID=01XC4Dr. Cowley gave me an update on ...

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Published on May 05, 2013

Revised fundraising goal!

I am revising my fundraising goal down from $15,000 to $10,000 which means... I MADE IT! So this project will definitely go ahead! I was very fortunate to be able to obtain the Brca1 mutant mice fr...

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Published on Mar 23, 2013

Twitter ideas

It is always useful to get feedback about your experimental design so it was really great to get an additional experiment suggested by @boehninglab via twitter for my research project (I have attac...

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Published on Mar 15, 2013

Detailed experimental design

Detailed Experimental DesignPower calculation:55 pups will be bred and genotyped per group to give an 80% probability of showing a statistically significant difference (using p < 0.05) of detect...

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Great progress!!
Apr 11, 2017
Sequencing the genomes of all known kākāpō
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Thank you so much for your support Cath and Rob!!
Sep 04, 2014
Can We Defeat EBOLA with an Experimental CANCER Drug?
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Thanks for your suggestion Shawn! I did look into doing that but next gen sequencing is fairly expensive (nearly the same cost as doing the animal breeding expt as planned) and it had the limitation of not being able to determine potential health effects on the offspring.
May 02, 2013
Can we prevent the transmission of BRCA mutations?
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Sorry I don't understand your question - what do you mean by "that other thing"?
Mar 27, 2013
Can we prevent the transmission of BRCA mutations?
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This is definitely a possibility and if so then the experiment will not work. However, we don't know if replication is necessary in this instance to induce apoptosis. Apoptosis, DNA repair, and expression of PARP and BRCA all occur in sperm cells so it is necessary to conduct the experiment to determine if it will work.
Mar 25, 2013
Can we prevent the transmission of BRCA mutations?
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